A "celebrity" injection to help with weight loss on the way?

Retro

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It's funny how being rich and perhaps famous helps so much with weight loss and keeping fit and healthy, doesn't it? Well, it looks like part of the reason could be a weekly injection to suppress appetite that's popular with celebrities. No wonder. Well, it looks like us great unwashed are going to have access to it soon. Hopefully it will make weight loss efforts significantly more successful than the 95% failure rate we currently see.

Weekly weight-loss jabs that are popular with celebrities will soon be made available through high street chemists in England, despite controversy over their use.

Many people struggle to tackle obesity through diet and exercise alone as they often find they regain the weight that they lose.
Woman with a disgusted facial expression looks at the greasy hamburger.

However a range of drugs, initially used for people with type 2 diabetes, has shown promise in treating obesity, with trials revealing that when combined with supervised weight-loss coaching they help people lose significant amounts of weight.

These drugs, known as GLP-1 analogues, work by mimicking hormones that help people feel full after consuming food.

wegovy.jpg


 

Arizona

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"Experts said they consider Ozempic and Wegovy to be lifelong medications."



"Rubino led a 2021 study, published in the Journal of the American Medical Association, that found that people who took Wegovy regained two-thirds of the weight they had lost when they went off the drug."
 
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Retro

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And Wegovy has now been approved for use by the NHS. Let's hope it helps all those millions struggling with their weight.



Also, check out related thread:

 

Arizona

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We won't have generally affordable Ozempic or Wegovy in the US until generics become available many years from now.

And more primary care doctors/practitioners in the US need to specialize in weight loss/management. But the doctors are out there in decent numbers and relatively easy to find with a Google search.

I've been taking a low dose of metformin to help prevent a recurrence of prediabetes (along with exercising more, eating more sensible portions, etc). But I mostly take metformin because it seems to help with my hunger cravings to some degree. And the good thing about metformin is that it is dirt cheap even though it is a prescription medication -- cheaper than most weight loss supplements that are marketed to help regulate blood sugar.

Metformin doesn't cause major weight loss, but it can help prevent weight gain (which is arguably the most important aspect of weight management).
 
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Arizona

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...An ingredient found in the fat-busting drug, known as Semaglutide, mimics the role of a natural hormone, called GLP-1.

"This hormone is normally produced in response to detecting nutrients when we eat," Emma wrote in the Conversation.

GLP-1 is part of the signalling pathway that tells your body you have eaten, and prepare it to use the energy that comes from your food...

Foods that help GLP-1 levels:
  1. Avocados
  2. Nuts
  3. Lean protein sources like eggs
  4. Vegetables
  5. Whole grains

A healthy diet, high in GLP-1 stimulating nutrients can increase GLP-1 levels. This could be foods with good fats, like avocado or nuts, or lean protein sources like eggs. And foods high in fermentable fibres, like vegetables and whole grains, feed our gut bacteria, which then produce short chain fatty acids able to trigger GLP-1 secretion.

This is why high fat, high fibre and high protein diets can all help you feel fuller for longer. It’s also why diet change is part of both weight and type 2 diabetes management.
 
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Arizona

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And from a dopamine point of view, avocado or baked beans on whole wheat toast is usually less "addictive" than pizza or pastries.

On the more extreme side:


Dr Gearhardt and Dr DiFeliceantonio applied the standards used to determine nicotine was an addictive substance to highly-processed food as well.

The first was compulsive use, which they described as a person wanting to eat the foods even when they were aware how unhealthy they are.

'People want to cut down, people go on diets and a vast majority of people fail,' Dr Gearhardt told DailyMail.com.

'They find it difficult to do so even when they know its going to kill them.'

She blamed the fat and sugar contents of the foods for triggering an addictive response in the brain.

But BMI would have to be very high (40+) to be comparable to the effects of cigarette smoking:


At 30-35 kg/m(2), median survival is reduced by 2-4 years; at 40-45 kg/m(2), it is reduced by 8-10 years (which is comparable with the effects of smoking). The definite excess mortality below 22.5 kg/m(2) is due mainly to smoking-related diseases, and is not fully explained.

(This is why the research continues to show that cigarette smoking is worse than obesity for individuals, though the effect of obesity on the healthcare system is greater given the greater prevalence of obesity than smoking.)
 
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